Indole-3-carbinol prevents the conversion of estrogens to substances that are associated with breast or prostate cancer. VitImmune’s Indole-3-Carbinol is formulated with DIM allowing the Indole-3-carbinol to exist for longer periods in the body.

Indole-3-Carbinol is one of the major antioxidant and hormone balancing substances found in cruciferous (cabbage family) vegetables. It is a member of the class of sulfur-containing chemicals called glucosinolates. It is formed from parent compounds whenever cruciferous vegetables are crushed or cooked. Indole-3-Carbinol and other glucosinolates (e.g., other indoles and isothiocyanates such as sulforaphane) are antioxidants and potent stimulators of natural detoxifying enzymes in the body. Indole-3-Carbinol is also used to balance hormone levels, detoxify the intestines and liver, and to support the immune system.

Function
Feeding Indole-3-Carbinol or broccoli extracts rich in Indole-3-Carbinol has dramatically reduced the frequency, size, and number of tumors in laboratory rats exposed to a carcinogen. It has a number of actions, including an ability to increase the breakdown of potentially harmful estrogens. The estrogen metabolites 16 alpha-hydroxyestrone and 4-hydroxyestrone have been demonstrated to be carcinogens in animal studies and maybe responsible for the possible carcinogenic effects of estrogen. On the other hand, the estrogen metabolite 2-hydroxyestrone has been found not to mimic the 16 alpha-hydroxy estrogen metabolite’s effects of stimulating tissue growth. Indole-3-Carbinol has been shown to increase the ratio of 2-hydroxyestrone to 16 alpha-hydroxyestrone and also to inhibit the 4-hydroxylation of estradiol. Indole-3-Carbinol increases 2-hydroxylation of estrogens via induction of cytochrome P4501A1 (CYP1A1). Indole-3-Carbinol is converted by stomach acid to diindolymethane (DIM) and indole (3,2,b) carbazole (ICZ). DIM and ICZ have similar activities regarding estrogen metabolism.

Indole-3-Carbinol has also been shown to modulate the activities of both Phase I enzymes, such as cytochrome P4501A1, -1A2, -2B1, -2B2, -3A1 and -3A2, and Phase II enzymes, such as glutathione S-transferase (GST), quinone reductase and uridine glucuronide transferase and accelerate the detoxification of carcinogens such as benzo(a)pyrene, aflatoxin B1 and 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone (NNK). Indole-3-Carbinol has also been shown to increase cell suicide (apoptosis) in in-vitro studies using cancer tissue cells.

As mentioned above, Indole-3-Carbinol induces the synthesis of 2-hydroxyestrone. 2-hydroxyestrone has been found to inhibit the oxidation of low-density lipoprotein. This indicates that Indole-3-Carbinol has an indirect antioxidant activity. 2-hydroxyestrone also appears to inhibit smooth muscle proliferation.

Committed to Quality
Vit-Immune carefully selects only the finest ingredients for use in Indole-3-Carbinol. Special chemical assays are performed on all the ingredients to insure purity, safety and potency.

Suggested Use: Take 2 capsules daily

Serving Size: 2 capsule, Servings per bottle: 30

Ingredients
Indole-3-Carbinol/DIM 200mgs

Cautions
Pregnant women and nursing mothers should avoid Indole-3-Carbinol supplements pending long-term safety studies. Those with cancer should confer with their physician before deciding to use Indole-3-Carbinol.
These statements have not been evaluated by the Food and Drug Administration. The FDA does not approve or disapprove over-the-counter supplements and this supplement is not meant to diagnose, treat, or prevent any clinical disease. Consult with your doctor before starting any supplemental or nutritional program. In the event of allergic reaction or accidental overdose, stop using the product immediately and seek emergency medical help. Not to be used in children.

Interactions
This product has no known interaction with any prescription or over-the-counter medications, however, it is our policy and as a precautionary measure to suggest that you speak to your prescribing doctor about using this product in conjunction with any prescription medications and before starting any nutritional program.

Adverse Reactions
If you experience allergic or adverse reactions stop and seek emergency assistance if necessary.